Fig. 7: Schematic illustration for MeCP2 regulating androgen via LHCGR and aromatase.
From: MeCP2 duplication causes hyperandrogenism by upregulating LHCGR and downregulating RORα
The illustration shows MeCP2 regulates its target genes (Lhcgr, Rorα) in the nucleus of the Leydig cell. The bold arrows (green or red) indicate that MeCP2 is involved in the testicular steroidogenesis by upregulating LHCGR and downregulating aromatase. TEST, testosterone.
