Fig. 7: CDK8 controls metastatic properties of TNBC cells and drives NK-cell immune evasion. | Cell Death & Disease

Fig. 7: CDK8 controls metastatic properties of TNBC cells and drives NK-cell immune evasion.

From: Triple-negative breast cancer cells rely on kinase-independent functions of CDK8 to evade NK-cell-mediated tumor surveillance

Fig. 7

CDK8 in TNBC drives invasion and metastatic dissemination of tumor cells and immune evasion (left box). Loss of CDK8 in tumor cells on the one hand, dampens invasiveness and pro-metastatic behavior of tumor cells and on the other hand, enhances recognition by NK cells, thereby decreasing tumor burden (right box).

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