Fig. 7: Cytokines detection and probable mechanism. | Cell Death & Disease

Fig. 7: Cytokines detection and probable mechanism.

From: The overexpression of Tipe2 in CRC cells suppresses survival while endogenous Tipe2 accelerates AOM/DSS induced-tumor initiation

Fig. 7

A The percentage of Tregs from IEL separated from Tipe2-defienct AOM/DSS models was significant lower than WT controls, especially with anti-CD25 treatment. Data were collected using BECKMAN COULTER CytoFLEXS, then analyzed using CytExpert. Tipe2-deficent AOM/DSS models showed lower serum levels of TGF-β (B) and IL-17 (C) with or without anti-CD25 antibody treatment. D Tipe2 inhibits tumor cell growth while promotes the initiation of AOM/DSS-induced colon cancer through regulating senescence.

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