Fig. 6: Potential regulation of KAT2A on cGAS in SLE. | Cell Death & Disease

Fig. 6: Potential regulation of KAT2A on cGAS in SLE.

From: A preliminary study of KAT2A on cGAS-related immunity in inflammation amplification of systemic lupus erythematosus

Fig. 6: Potential regulation of KAT2A on cGAS in SLE.The alternative text for this image may have been generated using AI.

Positive signals were shown as green fluorescence for cGAS, red for KAT2A, blue for DAPI (A); the obtained PBMCs from SLE group and healthy donors co-cultured with PBS or KAT2A inhibitor respectively. The expression level of cGAS pathway was detected by RT-PCR after co-culture for 24 h (B, C); the concentration of IFN-1 in the supernatant was detected by ELISA after co-culture (D); difference of detection indices after different treatment (co-cultured with PBS or KAT2A inhibitor) in the same sample (E−G). Samples from healthy donors or patients have inconsistent levels of this difference. *, **, *** and **** means p < 0.05, p < 0.01, p < 0.001 and p < 0.0001, respectively.

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