Fig. 3: Potential applications of patient-specific induced pluripotent stem cells for patients harboring ryanopathies. | Cell Death & Disease

Fig. 3: Potential applications of patient-specific induced pluripotent stem cells for patients harboring ryanopathies.

From: “Ryanopathies” and RyR2 dysfunctions: can we further decipher them using in vitro human disease models?

Fig. 3

Recapitulative scheme illustrating the potential use of hiPSC generated from a patient blood sample or somatic cells and carrying RyR2 mutation. Some isogenic control hiPSC could be generated by correcting the single-RyR2-point mutation using CRISPR/Cas9 technology. The hiPSC could then be differentiated into cardiomyocytes, neural and pancreatic cells. These generated cells could be used for disease modeling and drug screening approaches for a potential patient-specific cell therapy.

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