Fig. 5: Alleviation of the effects of UBA2 knockdown on 786-O cell proliferation and apoptosis via overexpression of the p53 mutant. | Cell Death & Disease

Fig. 5: Alleviation of the effects of UBA2 knockdown on 786-O cell proliferation and apoptosis via overexpression of the p53 mutant.

From: Knockdown of ubiquitin-like modifier-activating enzyme 2 promotes apoptosis of clear cell renal cell carcinoma cells

Fig. 5

A Expression levels of the p53 mutant and c-Myc in cells transfected with mp53-overexpressing and control plasmids. B Proliferation rates of cells in (A). C Expression levels of proapoptotic proteins in cells in (A). D Proportions of apoptotic cells in the populations of cells in (A). E PI staining of cells in (A). #p < 0.05 NC + mp53-OE vs. NC + EM; *p < 0.05 UBA2-KD + mp53-OE vs. UBA2-KD + EM. DAPI 4′,6-diamidino-2-phenylindole, PI propidium iodide, OE overexpression, KD knockdown, NC negative control, mp53 p53 mutant, EM empty vector.

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