Fig. 1: CircRELL1 is downregulated in GC and associated with poor prognosis. | Cell Death & Disease

Fig. 1: CircRELL1 is downregulated in GC and associated with poor prognosis.

From: Exosomal circRELL1 serves as a miR-637 sponge to modulate gastric cancer progression via regulating autophagy activation

Fig. 1

A Heat map analysis of circRNA expression profile in GC samples based on the GSE 100170. B Volcano plot showing circRNA transcript levels in GC and matched normal tissues. C The consistent circRELL1 expression between GSE 100170 and PMID27986464. D–F qRT-PCR results showing circRELL1 expression in 80 paired GC and adjacent normal gastric tissues. G, H Kaplan–Meier analysis of the correlation between circRELL1 expression and the overall survival (OS) and disease-free survival (DFS) based on circRELL1 expression levels. I Relative levels of plasma exosomal circRELL1 in GC patients (n = 64) and healthy controls (n = 64). J ROC analysis assessing the sensitivity and specificity of plasma exos-circRELL1 in predicting GC. K The expression of exosomal circRELL1 before and after gastrectomy (n = 64). L CircRELL1 sequence in CircBase (upper part) and validation with sanger sequencing (lower part). M Effect of RNase R on circRELL1 in HEK-293, AGS, and SGC-7901 cell lines. N, O Effect of actinomycin D on circRELL1 in AGS and SGC-7901 cell lines at the indicated time points. Data indicate mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.

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