Fig. 7: Diagram of the mechanism of NUSAP1 promoting DNA repair process by binding with RAD51. | Cell Death & Disease

Fig. 7: Diagram of the mechanism of NUSAP1 promoting DNA repair process by binding with RAD51.

From: Nucleolar and spindle associated protein 1 enhances chemoresistance through DNA damage repair pathway in chronic lymphocytic leukemia by binding with RAD51

Fig. 7: Diagram of the mechanism of NUSAP1 promoting DNA repair process by binding with RAD51.

RAD51 bound with the C-terminus of NUSAP1, meanwhile the SAP domain at the N-terminus of NUSAP1 may promote SUMOylation of RAD51, which prevented it from degradation, contributing to DNA damage repair pathway and promoting cancer cell growth or enhancing therapy resistance.

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