Fig. 3: Enrichment, transcription factor analysis and PPI of IMPC cluster in four samples. | Cell Death & Disease

Fig. 3: Enrichment, transcription factor analysis and PPI of IMPC cluster in four samples.

From: Spatial transcriptomics reveals gene expression characteristics in invasive micropapillary carcinoma of the breast

Fig. 3

A Highlight spatial hierarchical plot, GO enrichment (biological process, BP), KEGG enrichment and transcription factor analysis among top 50 gene in each IMPC cluster. GO, Gene Ontology. KEGG, Kyoto Encyclopedia of Genes and Genomes. The 30 terms with the lowest p.adjust values of the enrichment results were selected to draw the enrichment plot. The horizontal axis is gene and the vertical axis is term. The color represents the gene’s logFC value. p.adjust: use BH for multiple hypothesis testing, adjusted P value. p.adjust < 0.05 is a significant difference. Network diagram of highly expressed genes and transcription factors, the blue dots represent differential genes, and the purple dots represent transcription factors. The larger the node, the more nodes interacted to it. The arrows represent the enrichment terms related to metabolism, tumor immune response, and some important signaling pathways. B The t-SNE diagram of the integrated sequencing data. The four samples were completely distinguished. C, D The protein–protein interaction (PPI) plots of top 50 highly expressed genes in cluster 5 of sample 1 and cluster 2 of sample 4. The circles are nodes, and the size represents the size of the degree.

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