Fig. 3: Increased heterochromatin formation in Ras/Src tumor cells suppresses HDS-induced tumor growth. | Cell Death & Disease

Fig. 3: Increased heterochromatin formation in Ras/Src tumor cells suppresses HDS-induced tumor growth.

From: HP1a-mediated heterochromatin formation inhibits high dietary sugar-induced tumor progression

Fig. 3: Increased heterochromatin formation in Ras/Src tumor cells suppresses HDS-induced tumor growth.

Third instar eye discs of rasG12V; csk−/− and rasG12V, HP1a; csk−/− and rasG12V, HP1a-RNAi; csk−/− flies fed NDS or HDS; tumor cells are labeled with GFP (green). Scale bar: 100 μm. A, D rasG12V; csk−/−. B, E rasG12V, HP1a; csk−/−. C, F rasG12V, HP1a-RNAi; csk−/−. G, H Percentage of GFP-positive tumor cells normalized to total eye disc area from rasG12V; csk−/− and rasG12V, HP1a; csk−/− and rasG12V, HP1a-RNAi; csk−/− female or male flies fed NDS or HDS. All results analyzed and presented reflect data from five independent experiments (n = 50); results are shown as mean ± SD of individual eye discs. Asterisks indicate statistically significant differences (**p < 0.05; ***p < 0.01). GFP green fluorescent protein, HDS high dietary sugar, NDS normal dietary sugar.

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