Fig. 6: AOPPs induced osteoclastogenesis by RANK and RAGE signaling. | Cell Death & Disease

Fig. 6: AOPPs induced osteoclastogenesis by RANK and RAGE signaling.

From: Age-related accumulation of advanced oxidation protein products promotes osteoclastogenesis through disruption of redox homeostasis

Fig. 6: AOPPs induced osteoclastogenesis by RANK and RAGE signaling.

A, B Knockdown of RANK or RAGE suppressed the formation of TRAP positive cells induced by AOPPs. Scale bars = 200 μm. C Knockdown of RANK or RAGE decreased the TRAP activity, D Knockdown of RANK or RAGE inhibited gene expression of TRAP, MMP9, cathepsin K, and Oscar. E Knockdown of RANK or RAGE inhibited the expression of NFATc1 and phosphorylation of c-fos, F Knockdown of RANK or RAGE inhibited the formation of F-actin rings induced by AOPPs. Scale bars = 100 μm. G Knockdown of RANK or RAGE blocked AOPPs-induced bone resorption. Data expressed as mean ± SD. *p < 0.05 versus the vetor group; #p < 0.05 versus the AOPPs group.

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