Fig. 8: Molecular mechanism of tumor-derived extracellular vesicles delivering c-Myc affects gastric cancer growth and metastasis via the KCNQ1OT1/miR-556-3p/CLIC1 axis. | Cell Death & Disease

Fig. 8: Molecular mechanism of tumor-derived extracellular vesicles delivering c-Myc affects gastric cancer growth and metastasis via the KCNQ1OT1/miR-556-3p/CLIC1 axis.

From: Tumor-derived extracellular vesicles shuttle c-Myc to promote gastric cancer growth and metastasis via the KCNQ1OT1/miR-556-3p/CLIC1 axis

Fig. 8: Molecular mechanism of tumor-derived extracellular vesicles delivering c-Myc affects gastric cancer growth and metastasis via the KCNQ1OT1/miR-556-3p/CLIC1 axis.

Tumor-derived extracellular vesicles carrying c-Myc blocked miR-556-3p expression by upregulating KCNQ1OT1 to elevate CLIC1 expression,thus activating the PI3K/AKT pathway and accelerating gastric cancer cell proliferation, invasion, and migration.

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