Fig. 3: MeRIP-sequencing and RNA-sequencing combination interrogate the candidate target of METTL14. | Cell Death & Disease

Fig. 3: MeRIP-sequencing and RNA-sequencing combination interrogate the candidate target of METTL14.

From: TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4

Fig. 3

A, B RNA-sequencing determined differentially expressed genes between shM14 and shCON SW480 cells. C The statistically upregulated (red) and downregulated (green) genes were exhibited via volcano plot. D m6A peak number were detected in METTL14-knockdown group and control group. E Metagene profiles of m6A enrichment across mRNA transcriptome in SW480 cells. F Distribution and percentage of the differential peak in the genome. G The m6A consensus sequence motif was identified with m6A-sequecing data. H Heatmap showed 24 candidate genes came from the intersection of RNA-sequencing and MeRIP-sequencing.

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