Fig. 7: The proposed model for CAFs-derived IL-6/STAT3/LRG1 axis in promoting metastasis of CRC. | Cell Death & Disease

Fig. 7: The proposed model for CAFs-derived IL-6/STAT3/LRG1 axis in promoting metastasis of CRC.

From: Colorectal cancer-associated fibroblasts promote metastasis by up-regulating LRG1 through stromal IL-6/STAT3 signaling

Fig. 7: The proposed model for CAFs-derived IL-6/STAT3/LRG1 axis in promoting metastasis of CRC.

Scheme diagram depicting the underlying mechanism involved in metastasis of CRC mediated by CAFs. CAFs-derived IL-6 is able to activate JAK2-STAT3 in cancer cells. As a master transcriptional factor, STAT3 directly binds to LRG1 promoter, thus leading to upregulation of LRG1. LRG1 further promotes migration, invasion as well as EMT which is crucial for CAFs-mediated metastasis of CRC.

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