Fig. 4: PAARH facilitated HCC progression in vivo. | Cell Death & Disease

Fig. 4: PAARH facilitated HCC progression in vivo.

From: Long non-coding RNA PAARH promotes hepatocellular carcinoma progression and angiogenesis via upregulating HOTTIP and activating HIF-1α/VEGF signaling

Fig. 4: PAARH facilitated HCC progression in vivo.The alternative text for this image may have been generated using AI.

a Bioluminescence imaging of liver tumors in mice at day 14 after inoculation with small pieces of subcutaneous tumors formed by luciferase-labeled SNU-398 cells with PAARH stable overexpression or control. b Bioluminescence imaging of liver tumors in mice at day 14 after inoculation with small pieces of subcutaneous tumors formed by luciferase-labeled SNU-398 cells with PAARH stable silencing or control. c Ki67 IHC staining of liver tumors formed by SNU-398 cells with PAARH stable overexpression or control. Scale bars, 50 µm. d Ki67 IHC staining of liver tumors formed by SNU-398 cells with PAARH stable silencing or control. Scale bars, 50 µm. e TUNEL staining of liver tumors formed by SNU-398 cells with PAARH stable overexpression or control. Scale bars, 50 µm. f TUNEL staining of liver tumors formed by SNU-398 cells with PAARH stable silencing or control. Scale bars, 50 µm. g Microvessel density of liver tumors formed by SNU-398 cells with PAARH stable overexpression or control was detected using CD31 IHC staining. Scale bars, 100 µm. h Microvessel density of liver tumors formed by SNU-398 cells with PAARH stable silencing or control was detected using CD31 IHC staining. Scale bars, 100 µm. Results are shown as mean ± SD based on n = 6 mice in each group. *p < 0.05, **p < 0.01 by Mann–Whitney test (a, c, e, g) or Kruskal–Wallis test followed by Dunn’s multiple comparisons test (b, d, f, h).

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