Fig. 7: P2X7R antagonist’s treatment potentiates irradiation cytotoxic effects in GBM.
From: Irradiation causes senescence, ATP release, and P2X7 receptor isoform switch in glioblastoma
Percentage of surviving cells measured by soft agar assay at 28 days from radiation treatment in the absence or presence of P2X7R blockade with AZ10606120 or A740003 in GB40 (a, b) and GB48 (e, f). Data are shown as the mean ± SEM; n = 6. Heatmap shows the number of colonies (survival fraction) measured by soft agar assay at 28 days from radiation treatment in the absence or presence of P2X7R blockade in GB40 (c, d) and GB48 (g, h). Data were shown as the mean; n = 6. Combination index (CI) analysis of GB40 and GB48 cells treated with increasing concentrations of irradiation, AZ10606120 and A740003 are reported in white. The additive, synergistic, and antagonistic effect of the combinations was calculated using Compusyn Software (CI <1 synergism; CI = 1 additivity; CI >1 antagonism).
