Fig. 6: The ZNF32-LEPR signal was negatively correlated with the survival of CRC patients. | Cell Death & Disease

Fig. 6: The ZNF32-LEPR signal was negatively correlated with the survival of CRC patients.

From: ZNF32 promotes the self-renewal of colorectal cancer cells by regulating the LEPR-STAT3 signaling pathway

Fig. 6: The ZNF32-LEPR signal was negatively correlated with the survival of CRC patients.The alternative text for this image may have been generated using AI.

(A, B) IHC was used to analyze the expression of ZNF32 in tumor tissue (CRC) and adjacent normal tissue (AN). The positive cells were stained brown. The image is one represent of three independent experiments. (micron bar = 200 μm). (C, D) IHC to analyze the expression of LEPR in CRC and AN. The positive cells were stained brown. The image is one represent of three independent experiments. (micron bar = 50 μm). (E) Correlation analysis demonstrated that ZNF32 expression was positively correlated with LEPR expression in CRC tissues. (F) The survival status of patents was followed up, and Kaplan–Meier survival curves for these 100 patients were categorized into two groups based on the ZNF32 IHC score. (G) Kaplan–Meier survival curve for 78 patients (36 with high and 42 with low ZNF32 expression) who had received different cycles of chemotherapy (platinum combined with fluorouracil). Each experiment was performed at least in triplicate, and consistent results were obtained. The data presented here are from one representative experiment of three independent experiments and are presented as the means ± S.Ds.

Back to article page