Fig. 1: PTBP3 is overexpressed in CRC and is associated with a poor prognosis. | Cell Death & Disease

Fig. 1: PTBP3 is overexpressed in CRC and is associated with a poor prognosis.

From: PTBP3 modulates P53 expression and promotes colorectal cancer cell proliferation by maintaining UBE4A mRNA stability

Fig. 1

A PTBP3 mRNA level in the TCGA database (two-tailed Student’s t-test, P < 0.0001). B PTBP3 mRNA level in the GEO database (two-tailed Student’s t-test, P < 0.0001). C PTBP3 mRNA levels in CRC tissues compared with those in adjacent normal tissues (n = 30; measured by qRT-PCR; GAPDH was used as an internal control) (two-tailed Student’s t-test, P < 0.01). D PTBP3 protein levels in CRC tissues compared with those in adjacent normal tissues (n = 8; measured by Western blotting). E PTBP3 mRNA levels in colorectal cancer cell lines (HT29, SW480, HCT116, SW620 and LoVo) compared with those in FHC cells, a normal colon cell line (measured by qRT-PCR; GAPDH was used as an internal control) (two-tailed Student’s t-test, P < 0.05). F PTBP3 protein levels in colorectal cancer cell lines (HT29, SW480, HCT116, SW620 and LoVo) compared with those in FHC cells (measured by Western blotting). G Kaplan–Meier estimated overall survival in patients with high or low PTBP3 expression. Group cutoff-points: 25% (high) and 75% (low). The results are presented as means ± s.d. and are representative of at least three independent experiments.

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