Fig. 4: Inhibition of caspases prevents ARDS in P. berghei ANKA-infected DBA/2 mice. | Cell Death & Disease

Fig. 4: Inhibition of caspases prevents ARDS in P. berghei ANKA-infected DBA/2 mice.

From: Blockade of caspase cascade overcomes malaria-associated acute respiratory distress syndrome in mice

Fig. 4

Infected mice were treated with ZVA-fmk (5 mg/kg) with a single dose on the 3rd dpi. A Survival curve analyzed by the Log-rank test, where p < 0.05 (n = 20 mice); B Parasitemia throughout the infection; C increased respiratory pause (Penh), and D respiratory rate on the 7th dpi. Data representative of two independent experiments expressed with mean ± SEM by Mann–Whitney test (n = 3 NI; n = 10 control-infected mice; n = 10 infected and ZVAD-fmk-treated mice; **p < 0.01). ARDS: acute respiratory distress syndrome; HP: hyperparasitemia. E Photomicrographs of ARDS-developing mice lungs that died on the 10th day after infection (untreated controls) and ZVAD-fmk-treated. Note hemorrhagic and edematous areas in the control group (ARDS-developing mice); ×400 magnification; Scale bar 50 μm.

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