Fig. 1: Association of the stat4 rs7574865 genetic polymorphism with the risk of HCC. | Cell Death & Disease

Fig. 1: Association of the stat4 rs7574865 genetic polymorphism with the risk of HCC.

From: Stat4 rs7574865 polymorphism promotes the occurrence and progression of hepatocellular carcinoma via the Stat4/CYP2E1/FGL2 pathway

Fig. 1: Association of the stat4 rs7574865 genetic polymorphism with the risk of HCC.

A, B The relationship between the stat4 genetic polymorphism and clinical parameters: GGT (Control: TT + TG N = 127, GG N = 159; HCC: TT + TG N = 230, GG N = 269) and AST (Control: TT + TG N = 127, GG N = 159; HCC: TT + TG N = 230, GG N = 269) (*P < 0.05, P-value was calculated by Mann–Whitney U-test). C Kaplan–Meier survival curves for patients with HCC by stat4 genetic polymorphism (Serum: TT + TG N = 136, GG N = 178) P-values are depicted by Cox–Mantel log-rank test. D STAT4 expression in HCC patients and controls in human sera (Control: N = 60; HCC: N = 65). E, F STAT4 expression with different genotypes in human serum (HCC: TT + TG N = 42, GG N = 23 and Control: TT + TG N = 38, GG N = 22). G STAT4 expression in HCC patients and controls in human liver tissue (Control: N = 56; HCC: N = 42). H, I STAT4 expression with different genotypes in human liver tissue (HCC: TT + TG N = 13, GG N = 31; Control: TT + TG N = 25, GG N = 31) *P < 0.05, *P < 0.01, and ***P < 0.001 was assessed by Student’s t-test. J, L Survival curves of HCC patients with high and low STAT4 expression (Serum: N = 65; liver tissue: N = 42). K Kaplan–Meier survival curves for patients with HCC by stat4 genetic polymorphism (liver tissue: TT + TG N = 13, GG N = 31). P-values are depicted by Cox–Mantel log-rank test.

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