Fig. 7: The circRNA_37492 plasmid attenuated the UUO-induced renal fibrosis. | Cell Death & Disease

Fig. 7: The circRNA_37492 plasmid attenuated the UUO-induced renal fibrosis.

From: The mmu_circRNA_37492/hsa_circ_0012138 function as potential ceRNA to attenuate obstructive renal fibrosis

Fig. 7

C57BL/6 mice (male, 8–10 weeks of age) were injected with 300 μL saline in the absence or presence of 25 µg circ_37492 plasmid and then subjected to UUO or sham surgery. A–E The HE staining (A), Masson staining (B), and immunohistochemical staining of collagen I (C), collagen III (D), fibronectin (E) of renal tissue slices. (F) Quantification of fibrotic area (%) in the kidney cortex. G Quantification of immunohistochemical staining of type I collagen, type III collagen, and FN. H Quantification of protein band of type I collagen, type III collagen, FN, and Fgb in western blot. Original magnification, ×400. Scale bar, 100 μm. Quantitative data are presented as the mean ± SD (n = 6 per group). *p < 0.05, circRNA_37492 plasmid group or UUO group vs. double control group; #p < 0.05, circRNA_37492 plasmid with UUO group vs. UUO group.

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