Fig. 7: STING is the major sensor of diABZI-induced lung inflammation.
From: STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)
DiABZI (0.1 or 1 µg, i.t.) or saline were administered daily in STING−/−, cGAS−/−, NLRP3−/−, IFNAR−/−, AIM2−/−, TLR9−/−, and WT mice for 3 consecutive days and parameters analyzed on day 4. A–D Neutrophils (A), concentrations of dsDNA (B), IFNα (C), and CXCL10 (D) in BALF in WT and STING−/− mice. E–H. Neutrophils (E), dsDNA (F), IFNα (G), and CXCL10 (H) concentration in BALF in WT and cGAS−/− mice. I–L Neutrophils (I), dsDNA (J), IFNα (K), and CXCL10 (L) concentration in BALF in WT and NLRP3−/− and IFNAR−/− mice. M–P Neutrophils (M), dsDNA (N), IFNα (O), and CXCL10 (P) concentration in BALF in WT and AIM2−/− mice. R–U Neutrophils (R), dsDNA (S), IFNα (T), and CXCL10 (U) concentration in BALF in WT and TLR9−/− mice. Graph data were presented as mean ± SEM with n = 4–10 mice/group, each point representing an individual mouse. *p < 0.05, **p < 0.01, ***p < 0.001. (Nonparametric Kruskal–Wallis test followed by Dunn post test).
