Fig. 4: AMPC suppressed oncogenicity of PDAC cells. | Cell Death & Disease

Fig. 4: AMPC suppressed oncogenicity of PDAC cells.

From: Trefoil factor 3 promotes pancreatic carcinoma progression via WNT pathway activation mediated by enhanced WNT ligand expression

Fig. 4: AMPC suppressed oncogenicity of PDAC cells.

A BrdU assay showed that AMPC treatment for 48 hours inhibited the proliferative capability of SW1990 and Capan-1 cells in a dose-dependent manner. B Apoptosis after AMPC treatment for 48 hours was determined using AnnexinV/PI staining followed by FACS analysis. The percentages of cells in the early or late apoptotic phase are plotted. C Foci formation assay showed that AMPC treatment for attenuated foci formation of SW1990 and Capan-1 cells in a dose-dependent manner. D 3D-matrigel growth analysis showed that AMPC treatment attenuated 3D growth of SW1990 and Capan-1 cells in a dose-dependent manner; E 3D-matrigel growth analysis showed that AMPC treatment abrogated the increased 3D growth produced by forced expression of TFF3 in Capan-1 cells.

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