Fig. 8: Combination treatment of AMPC and WNT inhibitor suppressed xenograft growth and potentiated the efficacy of gemcitabine. | Cell Death & Disease

Fig. 8: Combination treatment of AMPC and WNT inhibitor suppressed xenograft growth and potentiated the efficacy of gemcitabine.

From: Trefoil factor 3 promotes pancreatic carcinoma progression via WNT pathway activation mediated by enhanced WNT ligand expression

Fig. 8: Combination treatment of AMPC and WNT inhibitor suppressed xenograft growth and potentiated the efficacy of gemcitabine.

A 3D-Matrigel growth analysis for SW1990 cells after AMPC, ICG-001, AMPC + ICG-001 (Double), gemcitabine (Gem) or AMPC + ICG-001 + Gem (Triple) treatment. The graph shows the spheroid volume in each group. Data represent means ± SD from at least three independent experiments. *P < 0.05, **P < 0.01, and ***P < 0.001. B Growth curve of SW1990-derived xenografts after treatment with vehicle, AMPC, ICG-001, Double, Gem, or Triple. n = 6 mice per group. Data are represented as means ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001. C Weights of the isolated SW1990-derived xenografts at the termination of the experiments. D Body weights of the mice during the treatment period. n = 6 mice per group. Data are represented as mean ± SD. *P < 0.05, **P < 0.01, and ***P < 0.001. E ELISA analysis for serum levels of human TFF3 derived from xenografts. F Representative micrographs of IHC staining for TFF3 and CTNNB1 in the indicated xenografts. Scale bar, 20 μm. G Representative micrographs and quantitative assay of IHC staining results for Ki67 in the indicated xenografts. Scale bar, 20 μm. Data are represented as means ± SD. *P < 0.05, **P < 0.01, and ***P < 0.001. H Representative micrographs and quantitative assay of TUNEL staining results in the indicated xenografts. Scale bar, 20 μm. Data are represented as means ± SD. *P < 0.05, **P < 0.01, and ***P < 0.001.

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