Fig. 3: Kcr levels are associated with HCC progression in Acox2−/− mice.
From: Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice
A Fluorescent immunohistochemistry using DAPI, anti-Ehhadh and pan anti-Kcr were performed on three slides of a single tumor focus. Scale bar, 25 μm. B Immunohistochemical staining showed Kcr signals were concentrated in the nucleus of tumor cells (upper panel) but mainly located in the cytoplasm of adjacent normal liver cells (bottom panel) in Acox2−/− mice, Scale bar, 3 μm. C Kcr levels were increased in the regions of bile duct proliferation in Acox2−/− mice by double immunostaining with Kcr and a ductal marker CK7. Co-localization of Kcr signal with CK7 was observed and indicated by white arrow. Representative images were displayed. Scale bar, 10 μm (upper) and 3 μm (bottom).
