Fig. 8: The regulation mechanism of RBM47/SNHG5/USP21/FOXO3 axis in PTC cells.

In brief, the upregulation of RBM47 inhibits PTC cell proliferation and active autophagy by binding to SNHG5. SNHG5 can recruited USP21, which interacts with FOXO3 to inhibit its ubiquitination and further promote its nuclear translocation. FOXO3 activates autophagy by promoting ATG3 and ATG5 transcription and activates RBM47 transcription to form a positive feedback loop.