Fig. 6: CCND1 depletion mitigates pro-tumor effects induced by CDC42EP3 overexpression.
From: CDC42EP3 promotes glioma progression via regulation of CCND1
CDC42EP3 overexpression (CDC42EP3 group), CCND1 knockdown (shCCND1 group) and CDC42EP3 overexpression + CCND1 knockdown (CDC42EP3 + shCCND1 group) cell models were constructed to carry out functional rescue experiments. A The comparison of cell proliferation between four cell groups resulted from Celigo cell counting assay. B Cell colony formation and the difference in colony numbers of four cell groups. C The comparison between percentage of apoptotic cells in four cell groups, derived from FACS. D Cellular ability of migration identified by wound-healing assay and the comparison of migration rate between different cell groups. E Representative images in Transwell assay and the differences in migration rate between four experimental cell groups. *P < 0.05, **P < 0.01, ***P < 0.001.
