Fig. 1: TRPM8 is upregulated and correlated with a poor prognosis in osteosarcoma. | Cell Death & Disease

Fig. 1: TRPM8 is upregulated and correlated with a poor prognosis in osteosarcoma.

From: AMTB, a TRPM8 antagonist, suppresses growth and metastasis of osteosarcoma through repressing the TGFβ signaling pathway

Fig. 1

A TRPM8 expression in osteosarcoma cells and MSC as determined by western blot (top) . Western blot is representative of five independent western blot with different lysates. TRPM8 levels for each compound was normalized to MSC cell values (bottom) . The data was compared by one-way ANOVA with Tukey’s multiple comparison test and shown as mean ± s.d. *P < 0.05. B, C Expression of TRPM8 in 57 osteosarcoma samples and paired adjacent non-tumoral samples as determined by IHC staining. D Kaplan–Meier survival rates for osteosarcoma patients with non/weak staining or moderate/strong staining of TRPM8.

Back to article page