Fig. 1: Treatment with Verapamil or TXNIP silencing reduce brain inflammation in 5xFAD mice.
From: RAGE-TXNIP axis drives inflammation in Alzheimer’s by targeting Aβ to mitochondria in microglia
A IHC analysis of TXNIP expression in 4 m old control and 5XFAD mice B Schematic representation of Verapamil and siTXNIP treatment in 5xFAD mice. C IHC analysis of TXNIP (green) and GFAP (red) in 4 m old control and 5xFAD mice hippocampus treated as indicated (n = 4). D ELISA analysis of TXNIP in control and 5xFAD mice hippocampus treated as indicated. One-way ANOVA followed by Tukey’s multiple comparison test (n = 4, ****p < 0.0001 versus control, ####p < 0.0001 versus siScramble). E, F Western blot analysis E and quantification F of GFAP in control and 5xFAD mice treated as indicated. One-way ANOVA followed by Tukey’s multiple comparison test (n = 3, ****p < 0.0001 versus control, ####p < 0.0001 versus siScramble). α-Actin was the load control.
