Fig. 4: RAGE–TXNIP axis is implicated in Aβ-induced changes in mitochondrial membrane potential, ROS formation.
From: RAGE-TXNIP axis drives inflammation in Alzheimer’s by targeting Aβ to mitochondria in microglia
A, B IF analysis (A) and quantification (B) of TMRM fluorescence in microglia treated as indicated. One-way ANOVA followed by Tukey’s multiple comparison test (n = 4; ****p < 0.0001 versus control; ####p < 0.0001 versus siScramble). C Quantification of JC-1 fluorescence ratio (520/590 nm) in microglia treated as indicated one-way ANOVA followed by Tukey’s multiple comparison test (n = 4; ****p < 0.0001 versus control; ####p < 0.0001 versus siScramble) D Quantification of CM-H2DCFDA fluorescence. One-way ANOVA followed by Tukey’s multiple comparison test (n = 12; ****p < 0.0001 versus control; ####p < 0.0001 versus siScramble). E Quantification of MytoSOX fluorescence. One-way ANOVA followed by Tukey’s multiple comparison test (n = 6; *p < 0.05, ****p < 0.0001 versus control; ####p < 0.0001 versus siScramble).
