Fig. 8: Expression of HspBP1 in normal and neoplastic breast tissues. | Cell Death & Disease

Fig. 8: Expression of HspBP1 in normal and neoplastic breast tissues.

From: HspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells

Fig. 8

A HapBP1 proteins in normal breast tissue, grade I/II, grade III/IV, and metastatic breast carcinoma are visualized using immunohistochemistry with an anti-HapBP1 antibody. The brown color indicates positive HspBP1 staining. Nuclei are stained with DAPI (blue). B Nuclear immunoreactivity for HspBP1 was blind-assessed and quantified by scoring for staining intensity and percent positive cells (see Materials and Methods) in tumor section of grade I/II, III/IV, metastasis, and normal tissue sections from the breast tissue microarray (total 85 samples). Results are shown as the mean ± SD (n = 3), **P < 0.01, *P < 0.05. C A schematic representing the role of HspBP1 in tumor suppression and apoptosis. See text for details.

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