Fig. 8: The diagram displaying the regulation of NFATc3 signaling by deSUMOylation under hypoxia. | Cell Death & Disease

Fig. 8: The diagram displaying the regulation of NFATc3 signaling by deSUMOylation under hypoxia.

From: Hypoxia-induced NFATc3 deSUMOylation enhances pancreatic carcinoma progression

Fig. 8: The diagram displaying the regulation of NFATc3 signaling by deSUMOylation under hypoxia.

Hypoxia resulted in SENP3-mediated deSUMOylation of NFATc3 at K384, suppressing the interaction between NFATc3 and its phosphokinase GSK-3β and subsequent increasing NFATc3 nuclear occupancy. In the nuclei of PDAC cells, NFATc3 formed complexes with other factors to coordinate target gene expression, which promoted PDAC progression.

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