Fig. 7: Anti-CXCL10 treatment attenuates CCl4-induced liver fibrosis.
From: MyD88 in hepatic stellate cells enhances liver fibrosis via promoting macrophage M1 polarization
Groups of MyD88fl/fl mice (n = 5 per group) were treated with CCl4 and anti-CXCL10 mAb or mIgG twice a week for 2 weeks. GFAPMyD88−/−mice were injected with CCl4 at the same time. These charts show the average of the experimental results, with the error bar showing the standard error of mean. a H&E and Sirius red staining of liver tissues. Scale bar, 50 μm. *p < 0.05. b immunofluorescence staining of CD86 in liver tissues. Scale bar, 50 μm, *p < 0.05. c The mRNA levels of IL-6 and iNOS in LX-2 cells were detected by qPCR, *p < 0.05. d Analysis of CXCL10 and CD86 expression in clinical samples from normal and cirrhosis patients in the GSE14323 database. Differences were analyzed by the log-rank test. ***p < 0.001. e Consecutive sections of liver tissues of cirrhosis patients for Sirius red and MyD88 immunofluorescence staining.
