Fig. 8: Schematic of MyD88 signaling in HSCs in fibrosis model.
From: MyD88 in hepatic stellate cells enhances liver fibrosis via promoting macrophage M1 polarization
MyD88 in HSCs promotes CXCL10 secretion. CXCL10 further induces macrophage M1 polarization through activation of JAK/STAT1 signaling pathway, which in turn promotes liver inflammatory response and fibrosis.
