Fig. 1: Differentially expressed circRNAs in AGS cells infected with Hp26695 vs. control.

a The number of reverse splicing events of circRNAs was identified in PBS-treated and Hp-infected AGS cells: 10,454 common circRNAs have two or more reverse splicing events. b The origin and distribution of circRNAs: exon circRNA (9%), intron circRNA (20%), intergenic region circRNA (21%), overlapping region circRNA (22%) and antisense circRNA (28%). c Length distribution of circRNAs (n = 18 308). d Heat map of the expression levels of circRNAs in AGS cells treated with PBS and Hp26695. (n = 6). Green to red represents circRNA expression from low to high, respectively. e Volcano plot of differentially expressed circRNAs: red dots indicate differentially expressed circRNAs; the left panel shows downregulated circRNAs, and the right panel shows upregulated circRNAs. (fold change > 2.0, P < 0.05, FDR < 0.05). f Scatter plots identified changes in circRNA expression (dots above the diagonal line indicate upregulated circRNAs, and dots below the diagonal line indicate downregulated circRNAs). g Chromosomal locus distribution of differentially expressed circRNAs. h The number of differentially expressed circRNAs.