Fig. 8: METTL3/STEAP2 m6A axis regulates hedgehog signaling pathway and EMT in PTC. | Cell Death & Disease

Fig. 8: METTL3/STEAP2 m6A axis regulates hedgehog signaling pathway and EMT in PTC.

From: METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition

Fig. 8: METTL3/STEAP2 m6A axis regulates hedgehog signaling pathway and EMT in PTC.The alternative text for this image may have been generated using AI.

BCPAP PTC cell lines were transfected with METTL3-overexpression (METTL3) plasmids and siRNA targeting STEAP2 (si-STEAP2) as indicated. A, B Effect of METTL3/STEAP2 axis on the expression of Hedgehog signaling pathway-related proteins (Smo, Gli1, and PTCH1) and EMT markers (E-cadherin, N-cadherin, snail, vimentin, and β-catenin) in PTC cells were quantified by western blot assay. C The graphic illustration of METTL3-mediated m6A modification modulating malignant phenotype of PTC through enhancing STEAP2 expression and then restraining Hedgehog signaling pathway and EMT. All data are presented as the mean ± standard deviation of three independent experiments. *P < 0.05, **P < 0.01, and ***P < 0.001.

Back to article page