Fig. 3: Upregulation of xCT in CRC cells promotes their migration and reverses the EMT process. | Cell Death & Disease

Fig. 3: Upregulation of xCT in CRC cells promotes their migration and reverses the EMT process.

From: xCT contributes to colorectal cancer tumorigenesis through upregulation of the MELK oncogene and activation of the AKT/mTOR cascade

Fig. 3

A–D Transwell assays indicated that xCT knockdown with xCT siRNA and xCT shRNA significantly suppressed the migration of CRC cells. E–G The wound scratch assay and quantitative analysis showed that xCT knockdown inhibited the migration of CRC cells. H–K IF staining indicated that xCT inhibition reduced the expression of vimentin (H–I) and N-cadherin (J–K) in CRC cells. L, M Western blot analysis confirmed that xCT knockdown decreased the expression of MMP1 and vimentin in CRC cells. N, O Transwell assays showed that overexpression of xCT promoted the migration of CRC cells. **P < 0.01, ***P < 0.001.

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