Fig. 1: Metabolic proteome signature of CD34+ leukemia cells. | Cell Death & Disease

Fig. 1: Metabolic proteome signature of CD34+ leukemia cells.

From: Mitochondrial oxidative phosphorylation is dispensable for survival of CD34+ chronic myeloid leukemia stem and progenitor cells

Fig. 1

A Diagram of experimental design. B Bar plots of top-ranked HALLMARK pathways that are significantly altered in CD34+ leukemia samples compared with the normal counterpart. NES: Normalized Enrichment Score. C The 2D plot of PCA between the CD34+ CML samples and normal samples. The differentially expressed proteins were used to carry out the analysis under the threshold of FC (fold change) >2 and P < 0.01. PCA1 and PCA2 denote the first and second principal component, respectively. D Correlation coefficient was calculated between the CD34+ cells protein log2 ratios (n = 5 patient samples, n = 5 normal samples) and transcript logFC in the four datasets (GSE24739, GSE43754, GSE47927, and GSE5550) using Pearson method. Filled black circles indicate all proteins/genes; filled red circles indicate regulated proteins/genes (FC > 2, P < 0.001). ra all proteins/genes correlation, rd deregulated proteins/genes correlation.

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