Fig. 7: The crosstalk between LCSCs and cellular components in the TME promotes stemness maintenance in HCC. | Cell Death & Disease

Fig. 7: The crosstalk between LCSCs and cellular components in the TME promotes stemness maintenance in HCC.

From: Mechanism of cancer stemness maintenance in human liver cancer

Fig. 7

Cellular components in the TME include tumor-associated macrophages, monocytes, fibroblasts, neutrophils, hepatic stellate cells, LECs, T cells, and B cells. Moreover, angiogenesis and the hypoxic microenvironment promote stem cell gene expression and tumorigenesis. OA osteoactivin.

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