Fig. 2: RAGE mediated the TGF-β1-induced expression of fibronectin & Col I&III & vimentin and RAGE in BUMPT cells.
From: Proximal tubular RAGE mediated the renal fibrosis in UUO model mice via upregulation of autophagy
The plasmid and siRNA of RAGE were transfected into BUMPT cells and treated with or without 5 ng/ml TGF-β1 for 24 h. A, G Immunoblot analysis of fibronectin & Col I&III, vimentin, and RAGE. B–F, H–L Analysis of the gray scale image between them. Data are expressed as means ± s.d. (n = 6). #P < 0.05 versus NC or Vector with the control group. *P < 0.05 versus NC or Vector with the TGF-β1 group. Each experiment (A, G) was repeated six times independently with similar results. B–F, H–L indicate the statistical Student’s t test used (means ± s.d., n = 6, P < 0.05).
