Fig. 6: Amelioration of UUO-induced renal fibrosis in PT-ATG7-KO mice.
From: Proximal tubular RAGE mediated the renal fibrosis in UUO model mice via upregulation of autophagy
The left ureter of PT-ATG7-KO and PT-ATG7-WT littermate mice was ligated for 7 days to establish a UUO model. A Hematoxylin and eosin staining and the representative Masson’s trichrome staining. B Quantification of tubulointerstitial fibrosis in the kidney cortex. C Immunohistochemistry of FN & Collagen I & Collagen III and α-SMA staining. D Quantification of the FN & Collagen I & Collagen III and α-SMA -positive cells in the kidney cortex. Original magnification ×400. Scale bar:100 µM. Data are expressed as means ± s.d. (n = 6). #P < 0.05 versus PT-ATG7-WT with the sham group. *P < 0.05 versus PT-ATG7-WT with the UUO group. Each experiment A, C was repeated six times independently with similar results. B, D indicate the statistical Student’s t test used (means ± s.d., n = 6, P < 0.05).
