Fig. 5: Behavioural impairments induced by liver-derived ApoE4. | Cell Death & Disease

Fig. 5: Behavioural impairments induced by liver-derived ApoE4.

From: Ageing related thyroid deficiency increases brain-targeted transport of liver-derived ApoE4-laden exosomes leading to cognitive impairment

Fig. 5: Behavioural impairments induced by liver-derived ApoE4.The alternative text for this image may have been generated using AI.

A Cognitive function in Morris water maze test. Time of escape latency and time in target quadrant were recorded and shown as mean ± SD, n = 6. B Motor function in rotarod and pole tests. Time on rod and T-LA time are shown as mean ± SD, n = 6. C Anxiety-like behaviours in open field test. Total travel distance and time spent in the central area were shown as mean ± SD, n = 6. D Depressive-like behaviours in tail suspension and forced swimming tests. Immobility time are shown as mean ± SD, n = 6. One-way ANOVA for comparisons including more than two groups; unpaired two-tailed t-test for two-group comparisons. Compared to adult group, *p < 0.05, **p < 0.01, ***p < 0.001.

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