Fig. 4: METTL14-mediated m6A modification represses LHPP expression in GC. | Cell Death & Disease

Fig. 4: METTL14-mediated m6A modification represses LHPP expression in GC.

From: m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer

Fig. 4: METTL14-mediated m6A modification represses LHPP expression in GC.The alternative text for this image may have been generated using AI.

A The potential m6A sites were predicted by SRAMP. B, C qRT-PCR and western blot assays revealed the mRNA and protein expression, respectively, of LHPP in GC cells with knockdown or overexpression of METTL14. D IHC staining of LHPP and METTL14 in TMAs. Scale bars = 200 μm. E m6A immunoprecipitation and qRT-PCR assays showed the relative percentage of LHPP mRNA with methylation. Data were analyzed using the Wilcoxon test. *P < 0.05, **P < 0.01, ***P < 0.001, ns no significant difference, GC gastric cancer, qRT-PCR quantitative reverse transcription-polymerase chain reaction, IHC immunohistochemical, TMS tissue microarrays.

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