Fig. 6: Combination therapy activates the integrative stress response and disrupts the NOXA.MCL-1.BIM axis, making stressed cells more prone to selection for apoptosis. | Cell Death & Disease

Fig. 6: Combination therapy activates the integrative stress response and disrupts the NOXA.MCL-1.BIM axis, making stressed cells more prone to selection for apoptosis.

From: Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors

Fig. 6: Combination therapy activates the integrative stress response and disrupts the NOXA.MCL-1.BIM axis, making stressed cells more prone to selection for apoptosis.

Western blots in CHLA06, BT37, and CHLA05 cell models of AT/RT 24 h after DMSO control treatment and increasing fixed dose ratios of combination TAK-228 and Obatoclax treatment. Numbers above phospho-EI2Fα (Ser51) represent quantification of expression normalized to EI2Fα. Numbers above other blots represent quantification of protein expression normalized to ACTIN.

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