Fig. 2: SAPAP3 expression in the hippocampus and cortex of the mouse model.
From: SAPAP3 regulates epileptic seizures involving GluN2A in post-synaptic densities
A Triple-label immunofluorescence showed that SAPAP3 (green) and GFAP (blue) were not coexpressed in astrocytes, but SAPAP3 (green) and MAP2 (red) were mainly coexpressed within mouse hippocampal (upper panel) and cortical neurons (middle panel). Triple-label immunofluorescence showed that SAPAP3 (green) and VGLUT1 (blue) were not coexpressed, but SAPAP3 (green) and PSD95 (red) were coexpressed (lower panel). B Representative western blot images and quantification of SAPAP3 expression showed a significant increase in SAPAP3 expression in the pilocarpine-induced mouse epilepsy model compared with controls (left panel, cortex; right panel, hippocampus). C Representative western blot images and quantification of SAPAP3 expression showed a significant increase in SAPAP3 expression in the PTZ-induced mouse epilepsy model compared with the controls (left panel, cortex; right panel, hippocampus). Data are presented as means ± SEM, n = 12 per group. *p < 0.05; **p < 0.01; ***p < 0.001.
