Fig. 3: Seizure-modifying effects of SAPAP3 on the pilocarpine-induced model and PTZ-kindling model.
From: SAPAP3 regulates epileptic seizures involving GluN2A in post-synaptic densities
A SAPAP3-sh treatment significantly increased the latency time to the first spontaneous seizures and B reduced the numbers of pilocarpine-induced spontaneous seizures in the chronic period. Recombinant SAPAP3 yielded the opposite results (A, B). Data are presented as means ± SEM, n = 8–10. *p < 0.05; **p < 0.01; ***p < 0.001. C SAPAP3-sh treatment significantly increased the latency time in the pentylenetetrazol-induced kindling model and E reduced the severity of pentylenetetrazol-induced seizures. Recombinant SAPAP3 yielded the opposite results (C, D). Data are presented as means ± SEM, n = 10. ***p < 0.001. F Representative EEG recording of pilocarpine-induced status epilepticus. G Typical EEG showing that mice with spontaneous recurrent seizures exhibited epileptic discharges.
