Fig. 5: Perturbations in the evoked EPSCs in response to changes in the SAPAP3 levels in the different groups.
From: SAPAP3 regulates epileptic seizures involving GluN2A in post-synaptic densities
A Representative traces of evoked AMPAR- (−70 mV) and NMDAR-mediated (+40 mV) EPSCs; NMDA receptor-mediated responses were measured at 50 ms poststimulus. B Summary graph showing that the NMDA/AMPA ratio was lower in the SAPAP3-sh-treated mice than in the controls. SAPAP3 overexpression from the recombinant SAPAP3 LV yielded the opposite results. C The SAPAP3-sh and SAPAP3 overexpression LV affected AMPAR-mediated EPSCs, but the difference was not significant. D The SAPAP3-sh LV significantly decreased the average amplitude of NMDAR-mediated EPSCs compared with that of the control group; SAPAP3 overexpression yielded the opposite results. E No significant difference in the PPRs for AMPAR-mediated EPSCs was found among the groups. Data are presented as means ± SEM, n = 6 per group. *p < 0.05; **p < 0.01; ***p < 0.001.
