Fig. 6: The functional relationship between UHMK1 and STAT3 in regulating cell proliferation and oxaliplatin resistance. | Cell Death & Disease

Fig. 6: The functional relationship between UHMK1 and STAT3 in regulating cell proliferation and oxaliplatin resistance.

From: UHMK1 aids colorectal cancer cell proliferation and chemoresistance through augmenting IL-6/STAT3 signaling

Fig. 6: The functional relationship between UHMK1 and STAT3 in regulating cell proliferation and oxaliplatin resistance.

A Cell viability was measured by CCK-8 assay in DLD-1/UHMK1-2 or SW620/UHMK1 cells with or without STAT3 knockdown. B CCK-8 assay in RKO and HCT-116 cells transfected with si-NC, siUHMK1-1, empty vector or STAT3 plasmid in a combined way as indicated. C Cell viability was measured by CCK-8 under gradient oxaliplatin treatment using cells as indicated in (A). D Cell viability was measured by CCK-8 under gradient oxaliplatin treatment using cells as indicated in (B). *p < 0.05, **P < 0.01. E Schematic diagram of the positive feedback loop between UHMK1 and STAT3.

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