Fig. 1: GCN5 expression is upregulated in hypertrophic mouse hearts and cardiomyocytes. | Cell Death & Disease

Fig. 1: GCN5 expression is upregulated in hypertrophic mouse hearts and cardiomyocytes.

From: GCN5-mediated regulation of pathological cardiac hypertrophy via activation of the TAK1-JNK/p38 signaling pathway

Fig. 1: GCN5 expression is upregulated in hypertrophic mouse hearts and cardiomyocytes.The alternative text for this image may have been generated using AI.

A–D EF values, FS values, HW/BW ratios, and HW/TL ratios in mice subjected to sham or TAC surgery at 2 or 4 weeks. E ANP, β-MHC, and GCN5 mRNA levels in the hearts of mice subjected to sham or TAC surgery. F ANP, β-MHC, and GCN5 protein levels in the hearts of mice subjected to sham or TAC surgery. (n = 4 mice/group, ∗P < 0.05 vs SHAM, ∗∗P < 0.01 vs SHAM) (G) ANP, β-MHC, and GCN5 mRNA levels in NRCMs treated with PBS or PE (50 μM). H ANP, β-MHC, and GCN5 protein levels in NRCMs treated with PBS or PE (∗∗P < 0.01 vs PBS). Data are shown as the mean ± SD from three independent experiments.

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