Fig. 3: GCN5 overexpression accelerates PE-induced cardiomyocyte hypertrophy and apoptosis. | Cell Death & Disease

Fig. 3: GCN5 overexpression accelerates PE-induced cardiomyocyte hypertrophy and apoptosis.

From: GCN5-mediated regulation of pathological cardiac hypertrophy via activation of the TAK1-JNK/p38 signaling pathway

Fig. 3: GCN5 overexpression accelerates PE-induced cardiomyocyte hypertrophy and apoptosis.The alt text for this image may have been generated using AI.

A Immunoblotting of primary cardiomyocytes infected with AdNull or AdGCN5 for 24 h to indicate GCN5 expression levels. B Effects of GCN5 overexpression on the mRNA levels of hypertrophic marker genes. C Effects of GCN5 overexpression on cardiomyocyte surface areas. D Western blots showing that overexpressed GCN5 exacerbates PE-induced NRCM apoptosis. E Representative images of TUNEL staining, indicating apoptotic rates of NRCMs (∗∗P < 0.01 vs AdNull PBS; #P < 0.05 vs AdNull PE, ##P < 0.01 vs AdNull PE). Data are shown as the mean ± SD from three independent experiments.

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